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Hormones may be to blame for these differences, said Kelly, who added that estrogen clearly plays a role in such conditions as migraines. Rates of other painful conditions increase for girls as they pass through puberty, whereas rates for adolescent boys are stable or rise less steeply. "Pain perception does vary according to the menstrual cycle phases in women with chronic pain," said Kelly. "For example, temporomandibular [jaw] pain, or TMJ, is highest in the pre-menstrual period and during menses." As for treating pain, studies have shown men and women experience different side effects of analgesic medications. There have also been studies into whether men respond better to opioid medications, but the findings are ambiguous at best, she said. However, research has shown that there are numerous factors involved in response to pain medications. "Genetic and hormonal differences may be the main reason for any differences, but it's becoming increasingly clear that social and psychological factors are also important," said Kelly. In her practice, Kelly treats the social and psychological factors in dealing with patients with chronic pain. She has made many observations of how women handle pain differently than men. "Women tend to focus on the emotional aspects of pain," she said. "Men tend to focus on the physical sensations they experience. Women who concentrate on the emotional aspects of their pain may actually experience more pain as a result, possibly because the emotions associated with pain are negative." Kelly offered these tips for better treatment of patients with chronic pain, especially women:
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